Gwen Lomberk Selected Research

Kruppel-Like Transcription Factors (Kruppel-Like Factors)

1/2021	Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells.
10/2015	Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.
8/2011	Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.
8/2011	Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis.

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Gwen Lomberk Research Topics

Disease

25	Neoplasms (Cancer) 01/2022 - 01/2007
17	Pancreatic Neoplasms (Pancreatic Cancer) 05/2021 - 01/2008
5	Carcinogenesis 01/2021 - 09/2010
5	Fibrosis (Cirrhosis) 01/2019 - 08/2011
3	Pancreatitis 01/2021 - 01/2009
3	Mason-Type Diabetes 10/2015 - 04/2012
2	Wounds and Injuries (Trauma) 08/2022 - 08/2021
2	Kabuki syndrome 01/2022 - 01/2021
2	Necrosis 08/2021 - 11/2018
2	Neoplasm Metastasis (Metastasis) 05/2021 - 09/2012
2	Adenocarcinoma 11/2019 - 09/2010
2	Inflammation (Inflammations) 01/2019 - 01/2017
2	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 01/2009
2	Liver Cirrhosis (Hepatic Cirrhosis) 12/2017 - 08/2011
2	Starvation 12/2015 - 10/2012
2	Diabetes Mellitus 10/2015 - 08/2011
2	Metabolic Diseases (Metabolic Disease) 05/2014 - 04/2012
2	Pain (Aches) 06/2013 - 01/2008
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/2022
1	Ischemia 08/2021
1	Reperfusion Injury 08/2021
1	Sarcoma (Soft Tissue Sarcoma) 01/2021
1	Chromosomal Instability (Chromosome Stability) 01/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2019
1	Kleefstra Syndrome 01/2017
1	Hearing Loss (Hearing Impairment) 01/2017
1	Body Weight (Weight, Body) 10/2015
1	Dyslipidemias (Dyslipidemia) 10/2015
1	Hepatocellular Carcinoma (Hepatoma) 01/2015
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2014
1	Obesity 05/2014
1	Hypoxia (Hypoxemia) 10/2012
1	Depressive Disorder (Melancholia) 07/2012

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2010
9	ChromatinIBA 01/2021 - 01/2007
5	Nuclear Proteins (Protein, Nuclear)IBA 05/2021 - 06/2012
5	Transcription Factors (Transcription Factor)IBA 01/2017 - 04/2012
4	Kruppel-Like Transcription Factors (Kruppel-Like Factors)IBA 01/2021 - 08/2011
3	Histones (Histone)IBA 01/2021 - 01/2016
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2020 - 10/2012
3	Messenger RNA (mRNA)IBA 01/2020 - 01/2015
3	Pharmaceutical PreparationsIBA 11/2017 - 01/2009
3	Insulin (Novolin)FDA Link 10/2015 - 01/2009
2	Histone DemethylasesIBA 01/2022 - 01/2021
2	Biological ProductsIBA 08/2021 - 06/2009
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 04/2021 - 12/2015
2	NUPR1 inhibitor ZZW-115IBA 01/2020 - 11/2019
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2017 - 07/2012
2	Blood Glucose (Blood Sugar)IBA 10/2015 - 01/2009
2	Factor XI (Plasma Thromboplastin Antecedent)IBA 06/2013 - 04/2012
1	dicarboxydine (DCD)IBA 08/2021
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 08/2021
1	Fluorouracil (Carac)FDA LinkGeneric 04/2021
1	Gemcitabine FDA Link 04/2021
1	Irinotecan (Camptosar)FDA LinkGeneric 04/2021
1	Docetaxel (Taxotere)FDA Link 04/2021
1	EnzymesIBA 01/2021
1	Histone-Lysine N-MethyltransferaseIBA 01/2021
1	Histone MethyltransferasesIBA 01/2021
1	Checkpoint Kinase 1IBA 01/2020
1	Intrinsically Disordered ProteinsIBA 11/2019
1	Inosine Diphosphate (IDP)IBA 11/2019
1	Hydroxyproline (4 Hydroxyproline)IBA 01/2019
1	Cysteine (L-Cysteine)FDA Link 01/2019
1	CollagenIBA 01/2019
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2019
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2019
1	TunicamycinIBA 11/2018
1	Adenosine Triphosphate (ATP)IBA 11/2018
1	Brefeldin AIBA 11/2018
1	ThapsigarginIBA 11/2018
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 12/2017
1	Ezetimibe (Zetia)FDA Link 11/2017
1	Annexin A1IBA 01/2017
1	Netrin-1IBA 01/2017
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2017
1	Adenosine (Adenocard)FDA LinkGeneric 01/2017
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2017
1	Peptides (Polypeptides)IBA 01/2017
1	PurinesIBA 01/2017
1	Galectins (Galectin)IBA 01/2017
1	LipoxinsIBA 01/2017
1	GasotransmittersIBA 01/2017
1	Choline (Choline Chloride)IBA 01/2016
1	Ethanolamine (Colamine)IBA 01/2016
1	Amino Acids FDA Link 10/2015
1	SulfatasesIBA 01/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2014
1	MethyltransferasesIBA 05/2014
1	CaspasesIBA 10/2012
1	Glucose (Dextrose)FDA LinkGeneric 10/2012
1	Aurora Kinase AIBA 10/2012
1	Oxygen (Dioxygen)IBA 10/2012
1	Monoamine Oxidase (MAO)IBA 07/2012

Therapy/Procedure

9	Therapeutics 01/2021 - 01/2009
3	Precision Medicine 08/2022 - 01/2017
3	Drug Therapy (Chemotherapy) 01/2021 - 01/2013
1	Liver Transplantation 08/2021
1	Ligation 01/2019
1	Pain Management 06/2013